Pregabalin IP 300mg (150 Capsules)

Here’s a detailed overview:

Indications

1. Neuropathic Pain: Effective in managing pain caused by nerve damage due to conditions like diabetes, shingles, spinal cord injury, or other neuropathic disorders.

2. Epilepsy: Used as adjunctive therapy for adults with partial-onset seizures.

3. Fibromyalgia: Helps in reducing widespread muscle pain and tenderness.

4. Generalized Anxiety Disorder (GAD): Approved in some regions for the treatment of GAD.

Dosage

Neuropathic Pain: Typically starts at 150 mg per day, divided into two or three doses. Based on efficacy and tolerability, the dose can be increased to 300 mg per day after one week. The maximum recommended dose is 600 mg per day.

Epilepsy: Similarly, the starting dose is often 150 mg per day, with potential increases based on response, up to a maximum of 600 mg per day.

Fibromyalgia: Often starts at 75 mg twice daily (150 mg per day) and can be increased to 150 mg twice daily (300 mg per day). Some patients may need up to 225 mg twice daily (450 mg per day).

Generalized Anxiety Disorder: Dosage may vary but often follows similar titration strategies, starting at lower doses and increasing based on response.

Side Effects

Common side effects include:

• Dizziness
• Somnolence (drowsiness)
• Dry mouth
• Edema (swelling, especially in extremities)
• Blurred vision
• Weight gain
• Difficulty concentrating

Less common but more serious side effects can include:

• Allergic reactions (rash, itching, swelling)
• Suicidal thoughts or behavior
• Angioedema (swelling under the skin)
• Severe muscle pain or weakness

Precautions

Kidney Function: Since Pregabalin is excreted renally, dose adjustments are necessary for patients with renal impairment.

Pregnancy and Breastfeeding: Pregabalin should only be used if the potential benefits justify the potential risks. It is classified as a Category C drug for pregnancy.

Alcohol and CNS Depressants: Concurrent use with alcohol or other CNS depressants can enhance the sedative effect, increasing the risk of side effects like dizziness and drowsiness.

Withdrawal: Abrupt discontinuation can lead to withdrawal symptoms; it should be tapered off gradually under medical supervision.

Storage

• Store at room temperature (20-25°C or 68-77°F).
• Keep away from moisture and light.
• Keep out of reach of children.

Administration Tips

• Capsules should be swallowed whole with water.
• Can be taken with or without food.
• Consistency in the timing of doses can help maintain steady blood levels of the medication.

If you have further questions or specific concerns regarding the use of Pregabalin, it’s important to consult with a healthcare provider or pharmacist who can provide personalised guidance based on your health status and medical history.